Exhaustive questioning will include whether they suffer from insomnia, what news websites they read, and whether they are familiar with various medications involved in the case.
The potential jurors will also be asked if they believe celebrities "get away with crimes because of their status" and "abuse their power." In a 30-page questionnaire they will also be asked if they have ever seen a member of the Jackson family in person or watched "This Is It," a film which included footage of the singer's final rehearsals.
Jackson stopped breathing at his Los Angeles mansion on June 25, 2009, in what authorities say was an overdose of the powerful anaesthetic propofol and various sedatives.
Murray, who has pleaded not guilty to involuntary manslaughter, has admitted giving Jackson a small amount of propofol to help him sleep but insists it was not enought to be fatal.
The doctor's lawyers have suggested that, when Murray was out of the room, Jackson could have given himself a large fatal dose of the drug.
Legal experts said it will be impossible to find anyone who knows nothing of Jackson, and lawyers on both sides will have to work through the jurors to find the most impartial.
Stan Goldman, a professor at Loyola Law School in Los Angeles, said: "It's going to be like a Ouija board, it's going to be guess work." Once a jury is selected, opening arguments are expected to begin the last week of September.